November 28th, 2007

Overdose in Children Involving Multi-Vitamins

I read this on Wikipedia (exact page):

A common unintentional overdose in young children involves multi-vitamins containing iron. Iron is a component of the hemoglobin molecule in blood, used to transport oxygen to living cells. When taken in small amounts, iron allows the body to replenish hemoglobin, but in large amounts it causes severe pH imbalances in the body. If this overdose is not treated with chelation therapy, it can lead to death or permanent coma.

I was wondering if that were to happen, like if two kids (4 and 6) their hands on their dad's multi-vitamins and died from an overdose, how many multi-vitamins would they have to take and how long would it be before they actually did die? Also, what sort of repercussions would there be for the parents if any?

The story is set in the United States in 2006 however the two kids died sometime 1992.

Thanks in advance to anyone who can help!

Genetic defect that leads to multiple organ failure

I'm looking for a genetic effect that causes some kind of deficiency in the human body, whatever that may be, which then in turn results in multiple organ failure. Due to the nature of this, I assume it would be a defect that usually manifests in early infancy as the baby would still be supplied with whatever the body is unable to produce itself while in the womb.

I've tried googling all kinds of combinations of the relevant keywords but somehow I can't really find anything useful since I'm totally lacking the proper knowledge to even come up with more specific search terms.

Any help would be appreciated. What kind of anything can a body fail to produce that'll lead to multiple organ failure? Oh yeah, it should also be treatable by simply replacing the lacking substance. Thanks!

Edit: Rarity isn't an issue. The rarer, the better even. And it doesn't totally have to be MOF if you can think of something better. Important is that it's a critical condition that can kill fast if left untreated.