Alice IW (alice_iw) wrote in little_details,
Alice IW

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Skin absorption of PCP?

Anybody know whether it's possible to absorb phencyclidine (PCP) in significant quantities (6-15 mg) topically through the genital mucous membranes -- and, if so, how long it might take to have neurological effects? I know that it's lipid soluble and that it's sometimes snorted, so clearly it can be absorbed through the skin & mucous membranes without being smoked. However, I haven't been able to find information that could let me guess how well it could be absorbed through such an... unlikely site.

Searches: 'skin absorption, phencyclidine', 'mucous membrane, absorption, phencyclidine', 'delivery, phencyclidine', 'cutaneous absorption, phencyclidine', etc., as well as various key phrases from the few promising-looking hits I found. Tox profiles/reference articles/research papers all seem to deal with the methods of recreational PCP use, which are primarily smoking and injection. (I found a pair of papers on inhibiting skin absorption in mice, but they were such as to be unhelpful for this particular question.)

Any educated guesses (hopefully no empirical data)?

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